Airlines with flights from Knoxville to Minneapolis
There are four airlines with scheduled flights between TYS and MSP. Delta is the only airline with non-stop flights from Mc Ghee Tyson to MSP Airport and the flight time is 2 hours and 34 minutes.
Choose airline
Schedules
Non-stop with Delta Air Lines
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Total flight time: 2 hours and 34 minutes
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Sky Team Alliance
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Minneapolis is a Delta Air Lines hub.
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19 flights per week
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Canadair (Bombardier) Regional Jet 900Canadair (Bombardier) Regional Jet 700 and Challenger 870
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First class available
TYS
Direct
MSP
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL5523
06:45
06:45
06:45
06:45
06:45
06:45
06:45
DL4803
18:42
18:42
18:42
18:42
18:42
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18:42
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 3h 55m - 6h 15m.
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Low-cost airline
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33 flights per week
TYS
Via BNA
MSP
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
WN3388
WN2160
WN2160
06:40
07:10
07:10
06:40
06:40
07:00
07:05
WN1768
WN4690
WN4690
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18:55
18:55
----
----
18:55
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The timetable & schedule information was updated at 2026-04-21
Via Chicago with American Airlines
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Total flight time: 3h 58m - 6h 55m.
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One World Alliance
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64 flights per week
TYS
Via ORD
MSP
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AA6449
AA3719
AA3719
----
----
----
----
----
07:44
----
AA6445
AA4000
AA4000
11:29
----
11:29
11:29
11:29
11:23
11:29
AA6456
AA4000
AA4000
----
----
----
----
----
13:04
----
AA6456
AA4425
AA4425
13:04
13:04
13:04
13:04
13:04
----
13:04
AA3603
AA4472
AA4472
18:39
18:39
18:39
18:39
18:39
19:12
18:39
The timetable & schedule information was updated at 2026-04-21
Via Chicago with United Airlines
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Total flight time: 4h 19m - 6h 42m.
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114 flights per week
TYS
Via ORD
MSP
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
UA2805
UA215
UA215
06:30
06:30
06:30
06:30
06:30
----
06:30
UA4780
UA215
UA215
08:20
08:20
08:20
08:20
08:20
----
----
UA3696
UA215
UA215
----
----
----
----
----
----
08:20
UA4578
UA1554
UA1554
10:45
10:45
10:45
10:45
10:45
10:45
10:45
UA5654
UA5587
UA5587
13:54
----
13:54
13:54
13:54
----
13:54
UA5654
UA3444
UA3444
----
13:54
----
----
----
13:54
----
UA2183
UA2005
UA2005
----
----
----
----
----
17:57
----
UA5469
UA2005
UA2005
17:57
17:57
17:57
17:57
17:57
----
17:57
The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
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Total flight time: 4h 19m - 6h 39m.
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Sky Team Alliance
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Minneapolis is a Delta Air Lines hub.
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33 flights per week
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Canadair (Bombardier) Regional Jet 900Canadair (Bombardier) Regional Jet 700 and Challenger 870
TYS
Via DTW
MSP
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL5341
DL2203
DL2203
11:41
11:41
11:41
11:41
11:41
----
11:41
DL4698
DL1303
DL1303
15:59
15:59
15:59
15:59
15:59
15:59
15:59
DL4697
DL1303
DL1303
17:25
17:25
17:25
17:25
17:25
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17:25
The timetable & schedule information was updated at 2026-04-21

There are four airlines with scheduled flights between TYS and MSP. Delta is the only airline with non-stop flights from Mc Ghee Tyson to MSP Airport and the flight time is 2 hours and 34 minutes.