Airlines with flights from Knoxville to Minneapolis

There are four airlines with scheduled flights between TYS and MSP. Delta is the only airline with non-stop flights from Mc Ghee Tyson to MSP Airport and the flight time is 2 hours and 34 minutes.

Choose airline

Schedules

Delta Air Lines

Non-stop with Delta Air Lines

  • Total flight time: 2 hours and 34 minutes
  • Sky Team Alliance
  • Minneapolis is a Delta Air Lines hub.
  • 19 flights per week
  • Canadair (Bombardier) Regional Jet 900
    Canadair (Bombardier) Regional Jet 700 and Challenger 870
  • First class available
TYS
Direct
MSP

The timetable & schedule information was updated at 2026-04-21

Southwest Airlines

Via Nashville with Southwest Airlines

  • Total flight time: 3h 55m - 6h 15m.
  • Low-cost airline
  • 33 flights per week
TYS
 
Via BNA
 
MSP

The timetable & schedule information was updated at 2026-04-21

American Airlines

Via Chicago with American Airlines

  • Total flight time: 3h 58m - 6h 55m.
  • One World Alliance
  • 64 flights per week
TYS
 
Via ORD
 
MSP
 
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AA6449
AA3719
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07:44
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AA6445
AA4000
11:29
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11:29
11:29
11:29
11:23
11:29
AA6456
AA4000
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----
----
----
----
13:04
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AA6456
AA4425
13:04
13:04
13:04
13:04
13:04
----
13:04
AA3603
AA4472
18:39
18:39
18:39
18:39
18:39
19:12
18:39
SHOW RETURN SCHEDULE
CHECK PRICES FOR TYS - MSP

The timetable & schedule information was updated at 2026-04-21

United Airlines

Via Chicago with United Airlines

  • Total flight time: 4h 19m - 6h 42m.
  • 114 flights per week
TYS
 
Via ORD
 
MSP
 
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
UA2805
UA215
06:30
06:30
06:30
06:30
06:30
----
06:30
UA4780
UA215
08:20
08:20
08:20
08:20
08:20
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UA3696
UA215
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----
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----
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08:20
UA4578
UA1554
10:45
10:45
10:45
10:45
10:45
10:45
10:45
UA5654
UA5587
13:54
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13:54
13:54
13:54
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13:54
UA5654
UA3444
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13:54
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----
----
13:54
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UA2183
UA2005
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----
----
----
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17:57
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UA5469
UA2005
17:57
17:57
17:57
17:57
17:57
----
17:57
SHOW RETURN SCHEDULE
CHECK PRICES FOR TYS - MSP

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Detroit with Delta Air Lines

  • Total flight time: 4h 19m - 6h 39m.
  • Sky Team Alliance
  • Minneapolis is a Delta Air Lines hub.
  • 33 flights per week
  • Canadair (Bombardier) Regional Jet 900
    Canadair (Bombardier) Regional Jet 700 and Challenger 870
TYS
 
Via DTW
 
MSP

The timetable & schedule information was updated at 2026-04-21

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Flight data on this page was last updated on 2026-06-02