Airlines with flights from Minneapolis to Knoxville
There are four airlines with scheduled flights between MSP and TYS. Delta is the only airline with non-stop flights from MSP Airport to Mc Ghee Tyson and the flight time is 2 hours and 17 minutes.
Choose airline
Schedules
Non-stop with Delta Air Lines
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Total flight time: 2 hours and 17 minutes
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Sky Team Alliance
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Minneapolis is a Delta Air Lines hub.
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13 flights per week
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Canadair (Bombardier) Regional Jet 700 and Challenger 870Canadair (Bombardier) Regional Jet 900
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First class available
MSP
Direct
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL5335
13:28
13:28
13:28
13:28
13:28
----
13:28
DL5527
19:45
19:45
19:45
19:45
19:45
19:45
19:45
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 3h 30m - 5h 20m.
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Low-cost airline
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30 flights per week
MSP
Via BNA
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
WN1528
WN4206
WN4206
07:05
07:05
07:05
07:05
07:05
----
06:15
WN1528
WN790
WN790
----
----
----
----
----
07:00
----
WN2962
WN694
WN694
16:00
15:10
15:10
16:00
16:00
----
----
WN2962
WN432
WN432
----
----
----
----
----
----
16:15
The timetable & schedule information was updated at 2026-04-21
Via Chicago with American Airlines
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Total flight time: 3h 57m - 6h 32m.
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One World Alliance
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54 flights per week
MSP
Via ORD
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AA4803
AA6456
AA6456
06:20
06:20
06:20
06:20
06:20
06:16
06:20
AA4000
AA6448
AA6448
15:43
----
15:46
15:43
15:43
17:17
15:43
The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
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Total flight time: 4h 00m - 5h 24m.
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Sky Team Alliance
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Minneapolis is a Delta Air Lines hub.
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17 flights per week
-
Canadair (Bombardier) Regional Jet 700 and Challenger 870Canadair (Bombardier) Regional Jet 900
MSP
Via DTW
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL1433
DL4698
DL4698
09:00
09:00
09:00
09:00
09:00
09:00
09:00
DL1519
DL4941
DL4941
12:55
12:55
12:55
12:55
12:55
----
12:55
DL1476
DL5138
DL5138
16:15
16:15
16:15
16:15
16:15
16:15
16:15
The timetable & schedule information was updated at 2026-04-21
Via Chicago with United Airlines
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Total flight time: 4h 01m - 6h 31m.
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145 flights per week
MSP
Via ORD
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
UA307
UA4714
UA4714
06:00
06:00
06:00
----
06:00
06:00
06:00
UA758
UA4714
UA4714
07:34
07:34
07:34
07:34
07:34
07:34
07:34
UA1929
UA5752
UA5752
09:52
09:52
09:52
09:52
09:52
----
09:52
UA576
UA625
UA625
----
----
----
----
----
11:32
----
UA576
UA5752
UA5752
11:32
11:32
11:32
11:32
11:32
----
11:32
UA1531
UA1732
UA1732
15:16
15:16
15:16
15:16
15:16
15:22
15:16
UA658
UA5860
UA5860
17:09
17:09
17:09
17:09
----
----
17:09
UA3532
UA5860
UA5860
----
18:41
----
----
----
----
----
UA5885
UA5860
UA5860
18:41
----
18:41
18:41
18:41
----
18:41
UA3532
UA3716
UA3716
----
----
----
----
----
18:41
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The timetable & schedule information was updated at 2026-04-21

There are four airlines with scheduled flights between MSP and TYS. Delta is the only airline with non-stop flights from MSP Airport to Mc Ghee Tyson and the flight time is 2 hours and 17 minutes.