Airlines with flights from Minneapolis to Knoxville

There are four airlines with scheduled flights between MSP and TYS. Delta is the only airline with non-stop flights from MSP Airport to Mc Ghee Tyson and the flight time is 2 hours and 17 minutes.

Choose airline

Schedules

Delta Air Lines

Non-stop with Delta Air Lines

  • Total flight time: 2 hours and 17 minutes
  • Sky Team Alliance
  • Minneapolis is a Delta Air Lines hub.
  • 13 flights per week
  • Canadair (Bombardier) Regional Jet 700 and Challenger 870
    Canadair (Bombardier) Regional Jet 900
  • First class available
MSP
Direct
TYS

The timetable & schedule information was updated at 2026-04-21

Southwest Airlines

Via Nashville with Southwest Airlines

  • Total flight time: 3h 30m - 5h 20m.
  • Low-cost airline
  • 30 flights per week
MSP
 
Via BNA
 
TYS

The timetable & schedule information was updated at 2026-04-21

American Airlines

Via Chicago with American Airlines

  • Total flight time: 3h 57m - 6h 32m.
  • One World Alliance
  • 54 flights per week
MSP
 
Via ORD
 
TYS

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Detroit with Delta Air Lines

  • Total flight time: 4h 00m - 5h 24m.
  • Sky Team Alliance
  • Minneapolis is a Delta Air Lines hub.
  • 17 flights per week
  • Canadair (Bombardier) Regional Jet 700 and Challenger 870
    Canadair (Bombardier) Regional Jet 900
MSP
 
Via DTW
 
TYS

The timetable & schedule information was updated at 2026-04-21

United Airlines

Via Chicago with United Airlines

  • Total flight time: 4h 01m - 6h 31m.
  • 145 flights per week
MSP
 
Via ORD
 
TYS
 
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UA307
UA4714
06:00
06:00
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06:00
06:00
06:00
UA758
UA4714
07:34
07:34
07:34
07:34
07:34
07:34
07:34
UA1929
UA5752
09:52
09:52
09:52
09:52
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09:52
UA576
UA625
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11:32
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UA576
UA5752
11:32
11:32
11:32
11:32
11:32
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11:32
UA1531
UA1732
15:16
15:16
15:16
15:16
15:16
15:22
15:16
UA658
UA5860
17:09
17:09
17:09
17:09
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17:09
UA3532
UA5860
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18:41
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UA5885
UA5860
18:41
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18:41
18:41
18:41
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18:41
UA3532
UA3716
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18:41
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SHOW RETURN SCHEDULE
CHECK PRICES FOR MSP - TYS

The timetable & schedule information was updated at 2026-04-21

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Flight data on this page was last updated on 2026-06-02