Airlines with flights from Knoxville to Chicago

There are three airlines with scheduled flights between TYS and MDW. Allegiant is the only airline with non-stop flights from Mc Ghee Tyson to Midway International Airport and the flight time is 1 hour and 36 minutes.

Choose airline

Schedules

Allegiant Air

Non-stop with Allegiant Air

  • Total flight time: 1 hour and 36 minutes
  • Low-cost airline
  • Knoxville is a Allegiant Air focus city (Operating base).
  • 2 flights per week
  • Airbus A320
TYS
Direct
MDW

The timetable & schedule information was updated at 2026-04-21

Southwest Airlines

Via Nashville with Southwest Airlines

  • Total flight time: 3h 10m - 7h 15m.
  • Low-cost airline
  • Chicago is a Southwest Airlines focus city (Operating base).
  • 25 flights per week
TYS
 
Via BNA
 
MDW

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Atlanta with Delta Air Lines

  • Total flight time: 3h 43m - 5h 51m.
  • Sky Team Alliance
  • 143 flights per week
TYS
 
Via ATL
 
MDW
 
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL3015
DL1063
05:40
05:40
05:40
05:40
05:40
06:00
05:40
DL5317
DL2417
07:33
07:33
07:33
07:33
07:33
----
07:33
DL5279
DL2417
08:35
08:35
08:35
08:35
08:35
----
----
DL1743
DL1728
11:55
11:55
11:55
11:55
11:55
----
11:55
DL2571
DL1076
18:05
18:05
18:05
18:05
18:05
----
18:05
DL4641
DL1076
----
----
----
----
----
18:07
----
SHOW RETURN SCHEDULE
CHECK PRICES FOR TYS - MDW

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Detroit with Delta Air Lines

  • Total flight time: 3h 55m - 6h 03m.
  • Sky Team Alliance
  • 28 flights per week
TYS
 
Via DTW
 
MDW

The timetable & schedule information was updated at 2026-04-21

Staying up-to-date with the airlines

At Airlineinformation.com you can learn all about the airlines operating around the world together with their destinations and where they operate. You will get a transparent overview of airlines with scheduled flights between any two destinations with non-stop or 1-stop flights regardless of price or availability.
Flight data on this page was last updated on 2026-06-02