Airlines with flights from Knoxville to Chicago
There are three airlines with scheduled flights between TYS and MDW. Allegiant is the only airline with non-stop flights from Mc Ghee Tyson to Midway International Airport and the flight time is 1 hour and 36 minutes.
Choose airline
Schedules
Non-stop with Allegiant Air
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Total flight time: 1 hour and 36 minutes
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Low-cost airline
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Knoxville is a Allegiant Air focus city (Operating base).
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2 flights per week
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Airbus A320
TYS
Direct
MDW
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
G41410
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13:22
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G41440
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13:22
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 3h 10m - 7h 15m.
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Low-cost airline
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Chicago is a Southwest Airlines focus city (Operating base).
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25 flights per week
TYS
Via BNA
MDW
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
WN3388
WN1473
WN1473
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07:10
07:10
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WN1768
WN4286
WN4286
19:45
18:55
18:55
19:45
19:45
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WN1768
WN578
WN578
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18:55
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WN1768
WN4277
WN4277
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19:00
The timetable & schedule information was updated at 2026-04-21
Via Atlanta with Delta Air Lines
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Total flight time: 3h 43m - 5h 51m.
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Sky Team Alliance
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143 flights per week
TYS
Via ATL
MDW
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL3015
DL1063
DL1063
05:40
05:40
05:40
05:40
05:40
06:00
05:40
DL5317
DL2417
DL2417
07:33
07:33
07:33
07:33
07:33
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07:33
DL5279
DL2417
DL2417
08:35
08:35
08:35
08:35
08:35
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DL1743
DL1728
DL1728
11:55
11:55
11:55
11:55
11:55
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11:55
DL2571
DL1076
DL1076
18:05
18:05
18:05
18:05
18:05
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18:05
DL4641
DL1076
DL1076
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18:07
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The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
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Total flight time: 3h 55m - 6h 03m.
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Sky Team Alliance
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28 flights per week
TYS
Via DTW
MDW
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
Sorry. We could not find any flights for this week.
The timetable & schedule information was updated at 2026-04-21

There are three airlines with scheduled flights between TYS and MDW. Allegiant is the only airline with non-stop flights from Mc Ghee Tyson to Midway International Airport and the flight time is 1 hour and 36 minutes.