Airlines with flights from Chicago to Knoxville
There are three airlines with scheduled flights between MDW and TYS. Allegiant is the only airline with non-stop flights from Midway International Airport to Mc Ghee Tyson and the flight time is 1 hour and 27 minutes.
Choose airline
Schedules
Non-stop with Allegiant Air
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Total flight time: 1 hour and 27 minutes
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Low-cost airline
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Knoxville is a Allegiant Air focus city (Operating base).
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2 flights per week
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Airbus A320
MDW
Direct
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
G41403
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14:46
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G41410
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14:46
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 3h 05m - 6h 40m.
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Low-cost airline
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Chicago is a Southwest Airlines focus city (Operating base).
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43 flights per week
MDW
Via BNA
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
WN3855
WN4206
WN4206
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06:10
WN1053
WN790
WN790
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06:40
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WN2959
WN4206
WN4206
07:15
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07:15
07:15
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WN1337
WN4206
WN4206
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07:55
WN3869
WN694
WN694
17:05
15:10
15:10
17:05
17:05
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WN1257
WN694
WN694
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15:30
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WN3614
WN432
WN432
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16:40
The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
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Total flight time: 3h 27m - 5h 02m.
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Sky Team Alliance
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7 flights per week
MDW
Via DTW
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL4674
DL4698
DL4698
09:17
09:17
09:17
09:17
09:17
09:17
09:17
DL4688
DL4941
DL4941
13:16
13:16
13:16
13:16
13:16
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13:16
The timetable & schedule information was updated at 2026-04-21
Via Atlanta with Delta Air Lines
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Total flight time: 3h 30m - 5h 53m.
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Sky Team Alliance
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121 flights per week
MDW
Via ATL
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
DL1285
DL1743
DL1743
06:05
06:05
06:05
06:05
06:05
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06:05
DL1285
DL4724
DL4724
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06:05
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DL1063
DL4641
DL4641
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10:55
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DL1063
DL2571
DL2571
11:05
11:05
11:05
11:05
11:05
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11:05
DL2417
DL3042
DL3042
12:45
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12:45
12:45
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12:45
DL2417
DL5416
DL5416
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12:45
12:45
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DL1728
DL2081
DL2081
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17:11
17:11
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DL1728
DL3072
DL3072
17:11
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17:11
17:11
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17:11
The timetable & schedule information was updated at 2026-04-21
Via Saint Louis with Southwest Airlines
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Total flight time: 5h 25m - 5h 25m.
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Low-cost airline
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Chicago is a Southwest Airlines focus city (Operating base).
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3 flights per week
MDW
Via STL
TYS
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
WN2903
WN694
WN694
14:45
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14:45
14:45
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The timetable & schedule information was updated at 2026-04-21

There are three airlines with scheduled flights between MDW and TYS. Allegiant is the only airline with non-stop flights from Midway International Airport to Mc Ghee Tyson and the flight time is 1 hour and 27 minutes.