Airlines with flights from Phoenix to Des Moines

There are five airlines with scheduled flights between PHX and DSM. Both American Airlines and Southwest operates non-stop flights from Phoenix Sky Harbor International to Des Moines International and the flight time is 2 hours and 51 minutes.

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Direct

$American Airlines from {( $airportFrom->city_name }} to Des Moines$

Non-stop

2h 51min

Direct

$Southwest Airlines from {( $airportFrom->city_name }} to Des Moines$

Non-stop

2h 40min

Via Denver

4h 5min

Via Denver

4h 19min

Via Denver

4h 20min

Via Las Vegas

4h 55min

Via Minneapolis

5h 2min

Via Dallas

5h 11min

NEW Starts 25/09

Via Salt Lake City

7h 30min

Schedules

Non-stop with American Airlines

Total flight time: 2 hours and 51 minutes
One World Alliance
Phoenix is a American Airlines hub.

14 flights per week
Airbus A319

Airbus A320
First class available

PHX

Direct

DSM

Flight

Mon

Jun 15

Tue

Jun 16

Wed

Jun 17

Thu

Jun 18

Fri

Jun 19

Sat

Jun 20

Sun

Jun 21

AA2516

08:55

08:54

AA568

18:50

19:00

18:50

19:00

18:50

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The timetable & schedule information was updated at 2026-04-21

Non-stop with Southwest Airlines

Total flight time: 2 hours and 40 minutes
Low-cost airline
Phoenix is a Southwest Airlines focus city (Operating base ).

4 flights per week

PHX

Direct

DSM

Flight

Sorry. We could not find any flights for this week.

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The timetable & schedule information was updated at 2026-04-21

Via Denver with Southwest Airlines

Total flight time: 4h 05m - 7h 05m.
Low-cost airline
Phoenix is a Southwest Airlines focus city (Operating base ).

149 flights per week

PHX

Via DEN

DSM

Flight

Mon

Jun 15

Tue

Jun 16

Wed

Jun 17

Thu

Jun 18

Fri

Jun 19

Sat

Jun 20

Sun

Jun 21

WN3259
WN1524

05:10

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05:10

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WN1706
WN1524

06:15

06:40