Airlines with flights from Chicago to Knoxville
There are four airlines with scheduled flights between ORD and TYS. Both American Airlines and United operates non-stop flights from Chicago O'Hare to Mc Ghee Tyson and the flight time is 1 hour and 48 minutes.
Choose airline
Schedules
Non-stop with American Airlines
-
Total flight time: 1 hour and 48 minutes
-
One World Alliance
-
Chicago is a American Airlines hub.
-
35 flights per week
-
Canadair (Bombardier) Regional Jet 700 and Challenger 870Embraer 175Embraer 170
-
First class available
Flight
The timetable & schedule information was updated at 2026-04-21
Non-stop with United Airlines
-
Total flight time: 1 hour and 48 minutes
-
Chicago is a United Airlines hub (Largest hub ).
-
28 flights per week
-
Canadair (Bombardier) Regional Jet 550Airbus A319Airbus A320Boeing 737-800 Passenger
-
Business and first class available
Flight
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
-
Total flight time: 3h 35m - 5h 25m.
-
Low-cost airline
-
10 flights per week
Flight
The timetable & schedule information was updated at 2026-04-21
Via Atlanta with Delta Air Lines
-
Total flight time: 3h 38m - 6h 04m.
-
Sky Team Alliance
-
214 flights per week
Flight
DL1743
DL4724
DL4724
DL4724
DL1148
DL4641
DL2571
DL5416
DL3042
DL5224
DL2081
DL3072
DL2081
The timetable & schedule information was updated at 2026-04-21
Via Charlotte with American Airlines
-
Total flight time: 3h 55m - 6h 30m.
-
One World Alliance
-
Chicago is a American Airlines hub.
-
218 flights per week
-
Canadair (Bombardier) Regional Jet 700 and Challenger 870Embraer 175Embraer 170
Flight
AA5950
AA5953
AA5831
AA5831
AA6439
AA5957
AA5957
AA5511
AA5511
The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
-
Total flight time: 3h 55m - 6h 07m.
-
Sky Team Alliance
-
43 flights per week
Flight
DL4698
DL4941
DL5138
The timetable & schedule information was updated at 2026-04-21

There are four airlines with scheduled flights between ORD and TYS. Both American Airlines and United operates non-stop flights from Chicago O'Hare to Mc Ghee Tyson and the flight time is 1 hour and 48 minutes.