Airlines with flights from Madrid to Istanbul

There are 9 airlines with scheduled flights between MAD and IST. Both Turkish Airlines and Air Europa operates non-stop flights from Barajas to Istanbul Airport and the flight time is 4 hours and 15 minutes.

Choose airline

Schedules

Turkish Airlines

Non-stop with Turkish Airlines

  • Total flight time: 4 hours and 15 minutes
  • Istanbul is a Turkish Airlines hub.
  • 24 flights per week
  • Airbus A321neo
    Airbus A321 (sharklets)
    Boeing 737-800 (winglets) Passenger/BBJ2
    Airbus A330-200
    Airbus A330-300
  • Business class available
MAD
Direct
IST

The timetable & schedule information was updated at 2026-04-21

Air Europa

Non-stop with Air Europa

  • Total flight time: 3 hours and 45 minutes
  • Sky Team Alliance
  • Madrid is a Air Europa hub.
  • 8 flights per week
  • Boeing 787
    Boeing 787-8
    Boeing 737-800 (winglets) Passenger/BBJ2
  • Business class available
MAD
Direct
IST

The timetable & schedule information was updated at 2026-04-21

Lufthansa

Via Munich with Lufthansa

  • Total flight time: 6h 40m - 7h 50m.
  • 14 flights per week
MAD
 
Via MUC
 
IST

The timetable & schedule information was updated at 2026-04-21

Lufthansa

Via Frankfurt with Lufthansa

  • Total flight time: 7h 00m - 10h 10m.
  • 35 flights per week
MAD
 
Via FRA
 
IST

The timetable & schedule information was updated at 2026-04-21

TAROM

Via Bucharest with TAROM

  • Total flight time: 7h 45m - 9h 05m.
  • Sky Team Alliance
  • 5 flights per week
MAD
 
Via OTP
 
IST

The timetable & schedule information was updated at 2026-04-21

Air Serbia

Via Belgrade with Air Serbia

  • Total flight time: 7h 55m - 7h 55m.
  • 5 flights per week
MAD
 
Via BEG
 
IST

The timetable & schedule information was updated at 2026-04-21

Staying up-to-date with the airlines

At Airlineinformation.com you can learn all about the airlines operating around the world together with their destinations and where they operate. You will get a transparent overview of airlines with scheduled flights between any two destinations with non-stop or 1-stop flights regardless of price or availability.
Flight data on this page was last updated on 2026-05-25