Airlines with flights from Madrid to Istanbul
There are 9 airlines with scheduled flights between MAD and IST. Both Turkish Airlines and Air Europa operates non-stop flights from Barajas to Istanbul Airport and the flight time is 4 hours and 15 minutes.
Choose airline
Schedules
Non-stop with Turkish Airlines
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Total flight time: 4 hours and 15 minutes
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Istanbul is a Turkish Airlines hub.
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24 flights per week
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Airbus A321neoAirbus A321 (sharklets)Boeing 737-800 (winglets) Passenger/BBJ2Airbus A330-200Airbus A330-300
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Business class available
Flight
The timetable & schedule information was updated at 2026-04-21
Non-stop with Air Europa
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Total flight time: 3 hours and 45 minutes
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Sky Team Alliance
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Madrid is a Air Europa hub.
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8 flights per week
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Boeing 787Boeing 787-8Boeing 737-800 (winglets) Passenger/BBJ2
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Business class available
Flight
The timetable & schedule information was updated at 2026-04-21
Via Munich with Lufthansa
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Total flight time: 6h 40m - 7h 50m.
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14 flights per week
Flight
LH1742
The timetable & schedule information was updated at 2026-04-21
Via Frankfurt with Lufthansa
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Total flight time: 7h 00m - 10h 10m.
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35 flights per week
Flight
LH1300
LH1300
LH1304
The timetable & schedule information was updated at 2026-04-21
Via Bucharest with TAROM
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Total flight time: 7h 45m - 9h 05m.
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Sky Team Alliance
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5 flights per week
Flight
RO265
The timetable & schedule information was updated at 2026-04-21
Via Belgrade with Air Serbia
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Total flight time: 7h 55m - 7h 55m.
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5 flights per week
Flight
JU426
The timetable & schedule information was updated at 2026-04-21

There are 9 airlines with scheduled flights between MAD and IST. Both Turkish Airlines and Air Europa operates non-stop flights from Barajas to Istanbul Airport and the flight time is 4 hours and 15 minutes.
Via Izmir with Pegasus
Via Paris with Air France
Via Algiers with Air Algerie
Via Athens with Aegean