Airlines with flights from Greenville to Chicago
There are four airlines with scheduled flights between GSP and ORD. Both American Airlines and United operates non-stop flights from Greenville-Spartanburg International to Chicago O'Hare and the flight time is 2 hours and 20 minutes.
Choose airline
Schedules
Non-stop with American Airlines
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Total flight time: 2 hours and 20 minutes
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One World Alliance
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Chicago is a American Airlines hub.
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27 flights per week
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Embraer 175
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First class available
Flight
The timetable & schedule information was updated at 2026-04-21
Non-stop with United Airlines
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Total flight time: 2 hours and 17 minutes
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Chicago is a United Airlines hub (Largest hub ).
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20 flights per week
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Embraer 175 (Enhanced Winglets)Canadair (Bombardier) Regional Jet 550
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First class available
Flight
The timetable & schedule information was updated at 2026-04-21
Via Charlotte with American Airlines
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Total flight time: 3h 44m - 6h 40m.
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One World Alliance
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Chicago is a American Airlines hub.
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210 flights per week
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Embraer 175
Flight
AA2843
AA1038
AA2908
AA2080
AA2080
AA536
AA2488
AA2488
AA627
AA3014
AA3014
The timetable & schedule information was updated at 2026-04-21
Via Atlanta with Delta Air Lines
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Total flight time: 3h 49m - 6h 20m.
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Sky Team Alliance
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211 flights per week
Flight
DL1147
DL1178
DL1147
DL2894
DL1477
DL2738
DL2738
DL2879
DL2486
DL2486
DL1199
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 4h 05m - 5h 45m.
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Low-cost airline
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2 flights per week
Flight
The timetable & schedule information was updated at 2026-04-21
Via Detroit with Delta Air Lines
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Total flight time: 4h 09m - 6h 23m.
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Sky Team Alliance
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7 flights per week
Flight
DL4683
DL3673
DL2358
The timetable & schedule information was updated at 2026-04-21

There are four airlines with scheduled flights between GSP and ORD. Both American Airlines and United operates non-stop flights from Greenville-Spartanburg International to Chicago O'Hare and the flight time is 2 hours and 20 minutes.