Airlines with flights from Detroit to Knoxville

There are four airlines with scheduled flights between DTW and TYS. Delta is the only airline with non-stop flights from Detroit Metropolitan Airport to Mc Ghee Tyson and the flight time is 1 hour and 41 minutes.

Choose airline

Schedules

Delta Air Lines

Non-stop with Delta Air Lines

  • Total flight time: 1 hour and 41 minutes
  • Sky Team Alliance
  • Detroit is a Delta Air Lines hub.
  • 29 flights per week
  • Canadair (Bombardier) Regional Jet 900
    Canadair (Bombardier) Regional Jet 700 and Challenger 870
  • First class available
DTW
Direct
TYS

The timetable & schedule information was updated at 2026-04-21

Southwest Airlines

Via Nashville with Southwest Airlines

  • Total flight time: 3h 25m - 5h 25m.
  • Low-cost airline
  • 18 flights per week
DTW
 
Via BNA
 
TYS

The timetable & schedule information was updated at 2026-04-21

American Airlines

Via Charlotte with American Airlines

  • Total flight time: 3h 30m - 6h 16m.
  • One World Alliance
  • 161 flights per week
DTW
 
Via CLT
 
TYS
 
Flight
Mon
Jul 13
Tue
Jul 14
Wed
Jul 15
Thu
Jul 16
Fri
Jul 17
Sat
Jul 18
Sun
Jul 19
AA387
AA5950
06:00
06:00
06:00
06:00
06:00
06:00
06:00
AA1439
AA5953
07:00
----
----
07:00
----
----
----
AA1791
AA5831
10:01
10:01
10:01
10:01
10:01
10:01
10:01
AA1781
AA6439
13:41
13:41
13:41
13:41
13:41
----
13:41
AA1770
AA5909
16:17
16:17
16:17
16:17
16:17
16:37
16:17
AA1794
AA5511
19:58
19:58
19:58
19:58
19:58
19:58
19:58
SHOW RETURN SCHEDULE
CHECK PRICES FOR DTW - TYS

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Atlanta with Delta Air Lines

  • Total flight time: 3h 37m - 6h 03m.
  • Sky Team Alliance
  • Detroit is a Delta Air Lines hub.
  • 277 flights per week
  • Canadair (Bombardier) Regional Jet 900
    Canadair (Bombardier) Regional Jet 700 and Challenger 870
DTW
 
Via ATL
 
TYS
 
Flight
Mon
Jul 13
Tue
Jul 14
Wed
Jul 15
Thu
Jul 16
Fri
Jul 17
Sat
Jul 18
Sun
Jul 19
DL2375
DL1290
05:20
05:20
05:20
05:20
05:20
05:20
05:20
DL1611
DL1743
06:20
06:20
06:20
06:20
06:20
----
06:20
DL965
DL4724
----
----
07:20
----
DL965
DL1743
07:20
07:20
07:20
07:20
07:20
----
07:20
DL1653
DL4724
08:25
08:25
08:25
08:25
08:25
08:25
08:25
DL2777
DL4724
09:25
09:25
09:25
09:25
09:25
----
09:25
DL2856
DL1148
10:25
10:25
10:25
10:25
10:25
----
10:31
DL2188
DL2571
12:25
12:25
12:25
12:25
12:25
----
12:25
DL2188
DL4641
----
----
----
----
----
12:25
----
DL1228
DL5416
----
14:59
14:59
----
----
----
----
DL1228
DL3042
14:59
----
----
14:59
14:59
----
14:59
DL1467
DL5416
----
----
----
----
----
14:59
----
DL1467
DL5203
15:59
15:59
15:59
15:59
15:59
----
15:59
DL2053
DL2081
----
18:38
18:38
----
----
17:59
----
DL2053
DL3072
18:38
----
----
18:38
18:38
----
18:38
SHOW RETURN SCHEDULE
CHECK PRICES FOR DTW - TYS

The timetable & schedule information was updated at 2026-04-21

American Airlines

Via Chicago with American Airlines

  • Total flight time: 3h 45m - 6h 16m.
  • One World Alliance
  • 90 flights per week
DTW
 
Via ORD
 
TYS

The timetable & schedule information was updated at 2026-04-21

Staying up-to-date with the airlines

At Airlineinformation.com you can learn all about the airlines operating around the world together with their destinations and where they operate. You will get a transparent overview of airlines with scheduled flights between any two destinations with non-stop or 1-stop flights regardless of price or availability.
Flight data on this page was last updated on 2026-06-29