Airlines with flights from Chicago to Des Moines

There are two airlines with scheduled flights between MDW and DSM. Southwest is the only airline with non-stop flights from Midway International Airport to Des Moines International and the flight time is 1 hour and 25 minutes. You can also connect with Delta via Minneapolis with a flight time of 3 hours and 49 minutes.

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Schedules

Southwest Airlines

Non-stop with Southwest Airlines

  • Total flight time: 1 hour and 25 minutes
  • Low-cost airline
  • Chicago is a Southwest Airlines focus city (Operating base).
  • 18 flights per week
  • Boeing 737MAX 8 Passenger
    Boeing 737-700 Passenger (Scimitar Winglets)
    Boeing 737-800 (winglets) Passenger/BBJ2
MDW
Direct
DSM

The timetable & schedule information was updated at 2026-04-21

Delta Air Lines

Via Minneapolis with Delta Air Lines

  • Total flight time: 3h 49m - 4h 47m.
  • Sky Team Alliance
  • 20 flights per week
MDW
 
Via MSP
 
DSM

The timetable & schedule information was updated at 2026-04-21

Staying up-to-date with the airlines

At Airlineinformation.com you can learn all about the airlines operating around the world together with their destinations and where they operate. You will get a transparent overview of airlines with scheduled flights between any two destinations with non-stop or 1-stop flights regardless of price or availability.
Flight data on this page was last updated on 2026-06-02