Airlines with flights from Medellin to Guayaquil

There are two airlines with scheduled flights between MDE and GYE. AVIANCA is the only airline with non-stop flights from Jose Maria Cordova to Simon Bolivar International and the flight time is 2 hours.

Choose airline

Schedules

AVIANCA

Non-stop with AVIANCA

  • Total flight time: 2 hours
  • Medellin is a AVIANCA hub (Secondary hub).
  • 3 flights per week
  • Airbus A320
    Airbus A320neo
  • Business class available
MDE
Direct
GYE

The timetable & schedule information was updated at 2026-04-21

AVIANCA

Via Bogota with AVIANCA

  • Total flight time: 4h 20m - 7h 40m.
  • Medellin is a AVIANCA hub (Secondary hub).
  • 252 flights per week
  • Airbus A320
    Airbus A320neo
MDE
 
Via BOG
 
GYE
 
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AV8435
AV8389
----
07:05
----
07:05
----
07:05
07:05
AV8435
AV77
07:05
----
07:05
----
07:05
----
----
AV9725
AV8389
----
07:40
----
07:40
----
07:40
07:40
AV9725
AV77
07:40
----
07:40
----
07:40
----
----
AV9243
AV8389
----
08:35
----
08:35
----
08:35
08:35
AV9243
AV77
08:35
----
08:35
----
08:35
----
----
AV8427
AV77
09:30
----
09:30
----
09:30
----
----
AV8427
AV8389
----
----
----
09:30
----
09:30
09:30
AV9463
AV8389
----
09:55
----
09:55
----
09:55
09:55
AV9463
AV77
09:55
----
09:55
----
09:55
----
----
AV8451
AV8383
----
10:40
10:40
10:40
10:40
10:40
10:40
AV9303
AV8383
11:55
11:55
11:55
11:55
11:55
11:55
11:55
AV9311
AV8383
13:15
13:15
13:15
13:15
13:15
13:15
13:15
AV9351
AV8391
16:55
16:55
16:55
16:55
16:55
16:55
16:55
AV9301
AV8391
17:35
17:35
17:35
17:35
17:35
17:35
17:35
AV9325
AV8391
18:55
18:55
18:55
18:55
18:55
18:55
18:55
SHOW RETURN SCHEDULE
CHECK PRICES FOR MDE - GYE

The timetable & schedule information was updated at 2026-04-21

Copa Airlines

Via Panama City with Copa Airlines

  • Total flight time: 4h 20m - 8h 35m.
  • 113 flights per week
MDE
 
Via PTY
 
GYE
 
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
CM151
CM273
05:00
05:00
05:00
05:00
05:00
05:00
05:00
CM209
CM273
06:25
06:25
06:25
06:25
06:25
06:25
06:25
CM164
CM258
08:35
----
----
08:35
----
08:35
----
CM398
CM378
09:15
09:15
09:15
09:15
09:15
09:15
09:15
CM757
CM378
10:35
10:35
10:35
10:35
----
10:35
----
CM506
CM378
12:40
12:40
12:40
12:40
12:40
12:40
12:40
CM154
CM213
15:10
15:10
15:10
15:10
15:10
15:10
15:10
CM766
CM213
16:30
16:30
16:30
16:30
----
16:30
----
CM157
CM301
18:20
18:20
18:20
18:20
18:20
18:20
18:20
SHOW RETURN SCHEDULE
CHECK PRICES FOR MDE - GYE

The timetable & schedule information was updated at 2026-04-21

AVIANCA

Via Quito with AVIANCA

  • Total flight time: 4h 40m - 5h 40m.
  • Medellin is a AVIANCA hub (Secondary hub).
  • 1 flights per week
  • Airbus A320
    Airbus A320neo
MDE
 
Via UIO
 
GYE

The timetable & schedule information was updated at 2026-04-21

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Flight data on this page was last updated on 2026-06-02