Airlines with flights from Medellin to Guayaquil
There are two airlines with scheduled flights between MDE and GYE. AVIANCA is the only airline with non-stop flights from Jose Maria Cordova to Simon Bolivar International and the flight time is 2 hours.
Choose airline
Schedules
Non-stop with AVIANCA
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Total flight time: 2 hours
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Medellin is a AVIANCA hub (Secondary hub).
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3 flights per week
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Airbus A320Airbus A320neo
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Business class available
MDE
Direct
GYE
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AV8399
16:50
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16:50
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16:50
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The timetable & schedule information was updated at 2026-04-21
Via Bogota with AVIANCA
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Total flight time: 4h 20m - 7h 40m.
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Medellin is a AVIANCA hub (Secondary hub).
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252 flights per week
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Airbus A320Airbus A320neo
MDE
Via BOG
GYE
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AV8435
AV8389
AV8389
----
07:05
----
07:05
----
07:05
07:05
AV8435
AV77
AV77
07:05
----
07:05
----
07:05
----
----
AV9725
AV8389
AV8389
----
07:40
----
07:40
----
07:40
07:40
AV9725
AV77
AV77
07:40
----
07:40
----
07:40
----
----
AV9243
AV8389
AV8389
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08:35
----
08:35
----
08:35
08:35
AV9243
AV77
AV77
08:35
----
08:35
----
08:35
----
----
AV8427
AV77
AV77
09:30
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09:30
----
09:30
----
----
AV8427
AV8389
AV8389
----
----
----
09:30
----
09:30
09:30
AV9463
AV8389
AV8389
----
09:55
----
09:55
----
09:55
09:55
AV9463
AV77
AV77
09:55
----
09:55
----
09:55
----
----
AV8451
AV8383
AV8383
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10:40
10:40
10:40
10:40
10:40
10:40
AV9303
AV8383
AV8383
11:55
11:55
11:55
11:55
11:55
11:55
11:55
AV9311
AV8383
AV8383
13:15
13:15
13:15
13:15
13:15
13:15
13:15
AV9351
AV8391
AV8391
16:55
16:55
16:55
16:55
16:55
16:55
16:55
AV9301
AV8391
AV8391
17:35
17:35
17:35
17:35
17:35
17:35
17:35
AV9325
AV8391
AV8391
18:55
18:55
18:55
18:55
18:55
18:55
18:55
The timetable & schedule information was updated at 2026-04-21
Via Panama City with Copa Airlines
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Total flight time: 4h 20m - 8h 35m.
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113 flights per week
MDE
Via PTY
GYE
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
CM151
CM273
CM273
05:00
05:00
05:00
05:00
05:00
05:00
05:00
CM209
CM273
CM273
06:25
06:25
06:25
06:25
06:25
06:25
06:25
CM164
CM258
CM258
08:35
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----
08:35
----
08:35
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CM398
CM378
CM378
09:15
09:15
09:15
09:15
09:15
09:15
09:15
CM757
CM378
CM378
10:35
10:35
10:35
10:35
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10:35
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CM506
CM378
CM378
12:40
12:40
12:40
12:40
12:40
12:40
12:40
CM154
CM213
CM213
15:10
15:10
15:10
15:10
15:10
15:10
15:10
CM766
CM213
CM213
16:30
16:30
16:30
16:30
----
16:30
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CM157
CM301
CM301
18:20
18:20
18:20
18:20
18:20
18:20
18:20
The timetable & schedule information was updated at 2026-04-21
Via Quito with AVIANCA
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Total flight time: 4h 40m - 5h 40m.
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Medellin is a AVIANCA hub (Secondary hub).
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1 flights per week
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Airbus A320Airbus A320neo
MDE
Via UIO
GYE
W25, Jun 15 - Jun 21
Flight
Mon
Jun 15
Tue
Jun 16
Wed
Jun 17
Thu
Jun 18
Fri
Jun 19
Sat
Jun 20
Sun
Jun 21
AV159
AV1670
AV1670
14:35
14:35
14:35
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14:35
----
14:35
AV159
AV1662
AV1662
----
----
----
14:35
----
14:35
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The timetable & schedule information was updated at 2026-04-21

There are two airlines with scheduled flights between MDE and GYE. AVIANCA is the only airline with non-stop flights from Jose Maria Cordova to Simon Bolivar International and the flight time is 2 hours.