Airlines with flights from Detroit to Greenville
There are four airlines with scheduled flights between DTW and GSP. Delta is the only airline with non-stop flights from Detroit Metropolitan Airport to Greenville-Spartanburg International and the flight time is 1 hour and 43 minutes.
Choose airline
Schedules
Non-stop with Delta Air Lines
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Total flight time: 1 hour and 43 minutes
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Sky Team Alliance
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Detroit is a Delta Air Lines hub.
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20 flights per week
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Canadair (Bombardier) Regional Jet 700 and Challenger 870Boeing 717-200
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First class available
DTW
Direct
GSP
W28, Jul 06 - Jul 12
Flight
Mon
Jul 6
Tue
Jul 7
Wed
Jul 8
Thu
Jul 9
Fri
Jul 10
Sat
Jul 11
Sun
Jul 12
DL5195
08:40
08:40
08:40
08:40
08:40
10:15
08:40
DL5090
16:24
16:21
16:21
16:21
16:21
----
16:21
DL1561
20:05
20:05
20:05
20:05
20:05
20:05
20:05
The timetable & schedule information was updated at 2026-04-21
Via Charlotte with American Airlines
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Total flight time: 3h 11m - 5h 56m.
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One World Alliance
-
173 flights per week
DTW
Via CLT
GSP
W28, Jul 06 - Jul 12
Flight
Mon
Jul 6
Tue
Jul 7
Wed
Jul 8
Thu
Jul 9
Fri
Jul 10
Sat
Jul 11
Sun
Jul 12
AA387
AA5799
AA5799
06:00
06:00
06:00
06:00
06:00
06:00
06:00
AA1439
AA5802
AA5802
07:00
----
----
07:00
07:00
----
07:00
AA1791
AA5805
AA5805
10:01
10:01
10:01
10:01
10:01
10:01
10:01
AA1781
AA5203
AA5203
13:41
13:41
13:41
13:41
13:41
----
13:41
AA1770
AA5524
AA5524
16:17
16:17
16:17
16:17
16:17
16:37
16:17
AA1794
AA5504
AA5504
19:58
19:58
19:58
19:58
19:58
19:58
19:58
The timetable & schedule information was updated at 2026-04-21
Via Washington with American Airlines
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Total flight time: 3h 27m - 6h 01m.
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One World Alliance
-
34 flights per week
DTW
Via DCA
GSP
W28, Jul 06 - Jul 12
Flight
Mon
Jul 6
Tue
Jul 7
Wed
Jul 8
Thu
Jul 9
Fri
Jul 10
Sat
Jul 11
Sun
Jul 12
AA5244
AA5204
AA5204
07:00
07:00
07:00
07:00
07:00
07:00
----
The timetable & schedule information was updated at 2026-04-21
Via Atlanta with Delta Air Lines
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Total flight time: 3h 30m - 6h 00m.
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Sky Team Alliance
-
Detroit is a Delta Air Lines hub.
-
270 flights per week
-
Canadair (Bombardier) Regional Jet 700 and Challenger 870Boeing 717-200
DTW
Via ATL
GSP
W28, Jul 06 - Jul 12
Flight
Mon
Jul 6
Tue
Jul 7
Wed
Jul 8
Thu
Jul 9
Fri
Jul 10
Sat
Jul 11
Sun
Jul 12
DL2375
DL3089
DL3089
----
05:20
05:20
05:20
05:20
05:20
05:20
DL1611
DL2158
DL2158
----
06:20
06:20
06:20
06:20
----
06:20
DL1611
DL1725
DL1725
06:20
----
----
----
----
----
----
DL965
DL1725
DL1725
07:20
07:20
07:20
07:20
07:20
07:20
07:20
DL1653
DL1725
DL1725
08:25
08:25
08:25
08:25
08:25
08:25
08:25
DL2777
DL1273
DL1273
09:25
09:25
09:25
09:25
09:25
09:25
09:25
DL2856
DL1273
DL1273
10:25
10:25
10:25
10:25
10:25
10:25
10:31
DL2188
DL3095
DL3095
12:25
12:25
12:25
12:25
12:25
12:25
12:25
DL1228
DL1021
DL1021
14:58
14:59
14:59
14:59
14:59
----
14:59
DL1467
DL1021
DL1021
----
----
----
----
----
14:59
----
DL1467
DL2319
DL2319
16:00
15:59
15:59
15:59
15:59
----
15:59
DL2053
DL2281
DL2281
18:38
18:38
18:38
18:38
18:38
17:59
18:38
DL2294
DL2281
DL2281
----
----
----
----
----
19:45
----
The timetable & schedule information was updated at 2026-04-21
Via Nashville with Southwest Airlines
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Total flight time: 3h 30m - 6h 55m.
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Low-cost airline
-
26 flights per week
DTW
Via BNA
GSP
W28, Jul 06 - Jul 12
Flight
Mon
Jul 6
Tue
Jul 7
Wed
Jul 8
Thu
Jul 9
Fri
Jul 10
Sat
Jul 11
Sun
Jul 12
WN4581
WN4622
WN4622
06:30
06:40
06:40
06:30
06:30
06:35
06:30
The timetable & schedule information was updated at 2026-04-21

There are four airlines with scheduled flights between DTW and GSP. Delta is the only airline with non-stop flights from Detroit Metropolitan Airport to Greenville-Spartanburg International and the flight time is 1 hour and 43 minutes.
Via Dulles with United